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The First-Pass Effect: How Your Gut Connects to Your Liver

Writer: Bianka Rainbow
Bianka Rainbow
Aug 25
1 min read

First-Pass Effect
First-Pass Effect

The First-Pass Effect: How Your Gut Connects to Your Liver

When you absorb something through your digestive tract, it doesn't simply circulate throughout your entire body first.

Many substances absorbed from the gut travel through the portal circulation directly to the liver, where metabolism can begin before they reach the rest of the body.

This is called the first-pass effect.

It’s one reason the gut and liver are so closely connected when we talk about how the body processes what we eat, drink, and absorb.

Your digestive system isn't simply taking things in. What enters through the gut can be transported directly to the liver for processing.

And your liver does SO much every single day.

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