Mood & Gut Health The Gut-Brain Connection: A Two-Way Conversation Most people think emotions begin in the brain, but your gut is actually the starting point  for many of your mood-regulating chemicals. In fact, over 70% of neurotransmitters like serotonin, dopamine, and GABA are created in the gut and then travel to the brain through the vagus nerve. When your gut is inflamed or affected by toxic overload, this communication becomes disrupted — and your mood often goes along