Vitamin E What Is Vitamin E? Vitamin E is a fat-soluble antioxidant essential for maintaining cellular integrity and protecting the body from oxidative stress. It exists in eight naturally occurring forms , divided into two categories: Tocopherols Tocotrienols Among them, alpha-tocopherol is the most biologically active form in the human body and the primary form measured in blood plasma. Because it dissolves in fat, Vitamin E is stored in body tissues and incorporated into