MSM MSM is often thought of only as a supplement for joints, but its most fascinating effects are at the cellular and biochemical level — particularly in modulating inflammation and oxidative stress. 🔬 1. Modulating Key Inflammatory Pathways Research shows MSM can reduce the activity of NF-κB, a major regulator of inflammatory cytokines. Lower NF-κB activity = reduced IL-6 and TNF-α, which are often involved in chronic inflammation. 🧪 2. Supporting Antioxidant Systems MSM