Parasites & Mast Cells Parasites & Mast Cells: A Root-Cause Connection That’s Often Missed Mast cells are often reduced to “allergy cells,” but this oversimplification misses their true biological role. Mast cells are front-line immune sentinels , strategically positioned in the gut, skin, lungs, and nervous system — precisely where parasites interface with the human host. Their primary function is not to cause symptoms, but to detect threats and coordinate immune defense .