MSM & Gut Barrier MSM and the Intestinal Barrier: What the Research Suggests Most people associate MSM (methylsulfonylmethane) with joint comfort and connective tissue support. However, a lesser-known area of research explores its potential impact on intestinal barrier integrity. The intestinal lining is composed of epithelial cells tightly connected by structures known as tight junctions . These junctions regulate what passes from the digestive tract into the bloodstream. T