Forever Chemicals (PFAS) You may have heard the term “forever chemicals” floating around lately — and for good reason. These compounds, scientifically known as PFAS (per- and polyfluoroalkyl substances) , are increasingly recognized as a serious and ongoing health concern. PFAS are a large group of synthetic chemicals designed to resist heat, water, oil, and degradation . That resistance is exactly why they’re useful industrially — and why they’re so problematic biologically