Serotonin Gut Serotonin: How Intestinal Inflammation Alters Mood and Motility Most people associate serotonin with the brain. However, approximately 90–95% of the body’s serotonin is produced in the gastrointestinal tract by specialized cells called enterochromaffin cells . In the gut, serotonin regulates: Peristalsis (movement of food) Secretion Visceral sensitivity Immune signaling These roles are well established in gastroenterology research. How Infections Affect Gut Se