Die-Off Explained Let’s talk about something that confuses a lot  of people when they start detoxing… Die-off. A friend once explained it in the simplest way possible: “What would happen if you called an exterminator to get rid of mice… but then just left them there?” Exactly. That “buildup” your body now has to process and eliminate? That’s essentially what die-off can feel like. What Is Detox Die-Off? Die-off (sometimes referred to as a Herxheimer reaction) can happen when