MTHFR & COMT 🌟 MTHFR & COMT: Understanding Your Genes for Better Wellness A friend of mine shared some powerful insights about these genes, and I knew I had to pass them on. If you’ve ever wondered how your genetics may influence your detox pathways, mood, or stress response, the MTHFR and COMT gene mutations are two place to start. Understanding these genes isn’t about fear—it’s about empowerment , epigenetics , and using simple steps to support your body more effectively.