Pineal Gland & Glymphatic System When we think of detox, most of us focus on the liver, kidneys, or gut—but the brain has its own specialized clearance system : the glymphatic system . Active primarily during slow-wave (deep NREM) sleep , it circulates cerebrospinal fluid (CSF) through perivascular channels, bathing neurons, glial cells, and the pineal gland . This nightly cleansing helps remove metabolic waste, small molecules, and toxic metals like aluminum  that can accumu